Hyaline Membrane Disease: Pathogenesis and Pathophysiology

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Prevention of Hyaline Membrane Disease

The high mortality of respiratory distress syndrome in premature infants and the relative ineffectiveness of treatment' make two recent reports of special interest. They are clinical studies2 3 which attempt to clarify the role of corticosteroids in prevention and treatment. New forms of treatment for this puzzling disorder have sometimes been introduced without adequate trials, so that it is h...

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Hyaline membrane disease, alkali, and intraventricular haemorrhage.

The relation between intraventricular haemorrhage (IVH) and hyaline membrane disease (HMD) was studied in singletons that came to necropsy at Hammersmith Hospital over the years 1966-73. The incidence of IVH in singleton live births was 3-22/1000 and of HMD 4-44/1000. Although the high figures were partily due to the large number of low birthweight infants born at this hospital, the incidence o...

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Hyaline membrane disease. II. Lung lecithin.

Boughton, K., Gandy, G., and Gairdner, D. (1970). Archives of Disease in Childhood, 45, 311. Hyaline membrane disease. H: Lung lecithin. The lecithin content of lung, together with its surface tension properties, were determined in 34 stillbirths, and 61 neonatal deaths. Lecithin content ranged widely from 1-5 to 18 6% of dry lung tissue. In 24 cases the 'palmitic-lecithin' was also measured; i...

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Assisted Ventilation in Terminal Hyaline Membrane Disease.

Goldsmith and Karotkin' researched the history of assisted ventilation and found that a record of mouth to mouth methods goes back to Old Testament times, and Hippocrates himself reported his experience with tracheal intubation to support pulmonary function. These skills were ignored for about 2000 years as it was not until the 16th century that attention was again paid to this subject when bel...

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Hyaline membrane disease. I. Cellular changes.

numerous granules usually indicated normal surfactant and their absence a lack. It is concluded that the granules represent surfactant material. Osmiophilic granules were found first at 20 weeks' gestation (in 2 out of 6 fetuses). After 24 weeks' gestation almost all infants had many granules, except those with HMD. The earliest stages in hyaline membrane formation consisted of interstitial oed...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1985

ISSN: 0007-1161

DOI: 10.1136/bjo.69.10.796-a